Comparative chemoreactomic analysis of ornithine aspartate, S-ademethionine and ursodeoxycholic acid

Purpose of the study. The pharmacological effects ornithine are primarily due to its participation in neutralization ammonia and metabolism amino acids. To clarify mechanisms action ornithine, a chemoreactom analysis aspartate was performed comparison with S-ademetionine (S-AM) ursodeoxycholic acid (UDCA). Methods. investigated substances on urates (derivatives uric acid), vasoactivity, vascular structure cytoprotection were assessed by method chemoreactome analysis. Results. It found that decrease blood urate levels is associated inhibition transporter URAT1 (ornithine – IC50 = 65 nM, S-AM 1060 UDCA 94 nM) xanthine oxidase 910 other molecules 9655-11040 nM). Among studied molecules, distinguished most pronounced vasodilatory properties (probably adrenergic receptors: Kd 35 1108-1428 highest antidyslipidemic activity also shown for (9.4 %) (10.2 %), lowest (4.6 %). effect endothelial lipase (IC50 258 nM ornithine). cytoprotective an increase glutathione synthesis, glutamatergic neurons under conditions glutamate stress, prostaglandin D-synthase, intensity acute lymphocytic inflammation without immunosuppression. Conclusion. Thus, results indicate significant expansion spectrum including not only hepatoprotection, but cardioprotection nephroprotection.